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Despite preliminary supporting evidence that the dopaminergic agent bupropion might improve sexual desire for female cancer survivors, the NRG Oncology CC004 clinical trial determined that bupropion did not improve outcomes when compared to a placebo. Though the results of this trial were negative, this study supports the urgent need to find effective treatment solutions for the large population of women who are concerned about side effects to their sexual desire following their cancer therapy. These results were published in the Journal of Clinical Oncology.

NRG-CC004 compared two dose-levels of extended-release bupropion in postmenopausal women who were diagnosed with breast or gynecologic cancer and completed their cancer treatment, but who had low baseline sexual desire scores (<3.3, atorvastatin sz 20mg out of a maximal score of 5) as determined by the desire subscale of the Female Sexual Function Index (FSFI). Women who participated on the trial were randomly assigned to receive either bupropion at 150 mg, bupropion at 300 mg, or placebo for 9 weeks. The loss of sexual desire in women who were treated for breast or gynecologic cancers is thought to be a response to one of two potential occurrences that are both related to dopamine insufficiency: estrogen deprivation or generalized inflammation. As a dopaminergic agent, various research suggests that bupropion might be an appropriate treatment option for loss of sexual desire, but NRG-CC004 exhibited no improvement from use of the agent.

“Cancer treatment can have a significant negative impact on female sexual function and is a common concern of female cancer survivors. Cancer survivors are expected to grow in population over the course of the next decade and over half of this population will be female,” stated Debra Barton, RN, Ph.D., of the University of Michigan School of Nursing and the lead author of the NRG-CC004 manuscript. “It is crucial that we continue to fund and support further research on the underlying characteristics of decreases in sexual health for these women and develop effective treatment options to improve their quality of life following treatment.”

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